Animal model studies in functional brain imaging (fMRI) require extremely high spatial resolutions, thus being challenged by the low signal-to-noise ratio (SNR). Recent advances in fMRI denoising provide gains by suppressing thermal noise. Here we demonstrate significant improvements of fMRI results by NORDIC (NOise reduction with DIstribution Corrected PCA) de-noising; increased functional CNR and T-statistics, yielded the high signal stability of single fMRI acquisition with reproducible quantification of brain responses.
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