We present a realistic cardiac MRI simulation framework, including concomitant effects, off-resonance, realistic coil-array and noise level. The general framework is flexible to different field strengths, sequences, and different motion patterns and ischemia models can be introduced. We demonstrate three usages of the framework, in comparing artifact/noise level at different field strengths, in optimization of real-time 3D trajectories and reconstruction, and capturing myocardial perfusion deficits. Real-time 3D cine and first-pass perfusion with high-resolution whole-heart coverage were tested feasible on a high-performance 0.55T system by simulation.
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