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Abstract #2822

Quantitative multi-modal MRI shows correlations between lesion iron deposition and neuro-axonal density in progressive multiple sclerosis

Sara Collorone1, Marco Battiston1, Ferran Prados 1,2,3, Alberto Calvi1, Baris Kanber4, Francesco Grussu1,5, Marios Yiannakas1, Carmen Tur1,6, Rebecca Samson1, Olga Ciccarelli1,7, and Claudia A.M. Gandini Wheeler-Kingshott1,8,9
1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, United Kingdom, 2Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London (UCL), London, United Kingdom, 3Universitat Oberta de Catalunya, Barcelona, Spain, 4Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London(UCL), London, United Kingdom, 5Radiomics Group, Vall d’Hebron Institute of Oncology, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, 6Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d’Hebron Institute of Research, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, 7University College London Hospitals, Biomedical Research Centre, National Institute for Health Research, London, United Kingdom, 8Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, 9Brain Connectivity Center Research Department, IRCCS Mondino Foundation, Pavia, Italy

We present preliminary results on ten patients with progressive multiple sclerosis(PMS) who underwent multi-modal MRI including quantitative magnetisation transfer (qMT), relaxometry and neurite orientation dispersion and density imaging (NODDI). We obtained metrics sensitive to iron deposition (T2*), myelin (restricted proton fraction (F)), and neuro-axonal density (neurite density index (NDI)) in lesions and brain tissues. Increased lesion T2* was related to decreased NDI in lesions and cortical grey matter. The lesion high T2* and low NDI were related to worse cognitive performance. In PMS, iron deposition from innate immune activity may lead to axonal loss and represent a future therapeutic target.

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