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Abstract #2820

Myelin Water Imaging Demonstrates Myelin Loss in Multiple Sclerosis Normal Appearing White Matter over Two Years

Irene Margaret Vavasour1, Poljanka Johnson2, Shawna Abel3, Stephen Ristow3, Jared Splinter3, Cornelia Laule1,4,5,6, Roger Tam1, David KB Li1, Nathalie Ackermans3, Alice J Schabas3, Jillian Chan3, Helen Cross3, Ana-Luiza Sayao3, Virginia Devonshire3, Robert Carruthers3, Anthony Traboulsee3, and Shannon H Kolind1,3,4,6
1Radiology, University of British Columbia, Vancouver, BC, Canada, 2Neuroscience, University of British Columbia, Vancouver, BC, Canada, 3Medicine, University of British Columbia, Vancouver, BC, Canada, 4Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 5Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 6International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada

Therapies that target remyelination are under development and a non-invasive specific and sensitive imaging biomarker to evaluate their efficacy within the timescale of a clinical trial is vital. Using myelin water imaging, we followed a group of relapsing-remitting and progressive multiple sclerosis (MS) participants and healthy controls over approximately 2 years to compare their rate of change in myelin water fraction. A significant decrease in mean myelin water fraction was found over 2 years in the normal-appearing white matter of participants with MS, with a larger decrease in relapsing-remitting MS than progressive MS.

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