Abstract #2818

High-b Diffusivity of MS Lesion in Cervical Spinal Cord using Ultrahigh-b DWI (UHb-DWI)

Kyle Jeong¹, Lubdha Shah², You-Jung Lee¹, Bijaya Thapa¹, Nabraj Sapkota¹, Erica Bisson³, Noel Carlson⁴, Eun-Kee Jeong², and John Rose⁵

¹Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States, ²Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, ³Neurosurgery, University of Utah, Salt Lake City, UT, United States, ⁴GRECC, Veterans Affairs, Salt Lake City, UT, United States, ⁵Neuroimmunology and Neurovirology Division, University of Utah, Salt Lake City, UT, United States

Ultrahigh-b radial DWI (UHb-rDWI) is a technique that can quantitatively evaluate MS lesions with respect to degrees of demyelination and axonal damage and/or loss. Currently, there is a lack of sensitive diagnostic technique to quantitatively and non-invasively grade cervical spinal cord (CSC) injury and repair. Our UHb-rDWI can potentially be a powerful tool to quantitatively observe disease progression and monitor treatment responses in MS CSC. Therefore, the main objective of this study was to investigate UHb-rDWI signal in white matter tracts of the CSC and compare quantitative values between healthy control WM with both MS NAWM and WM lesions.

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