Deep neural network was used to automatically segment diffusely abnormal white matter (DAWM) in 100 relapsing remitting multiple sclerosis patients (RRMS). Our calculated DAWM prevalence of 32% is comparable to ~ 25% reported elsewhere. Based on our studies, only 13% of T2 lesions at baseline converted into DAWM by 60 months. Of the DAWM detected at baseline, only 15% converted to lesions, 45% persisted, and 40% resolved (converted to NAWM). These initial results suggest that DAWM may present a significant disease burden by itself.
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