Abstract #2754

Comparison of multi-echo Dixon andmulti-echo MRS sequences to quantify hepatic iron overload in rabbits with or without fatty liver

Zhao Fan yu¹, Chen Yidi¹, Zhang Huiting², Stephan Kannengiesser³, and Long Liling¹

¹Radiology Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, China, ²Siemens Healthcare Ltd, MR Scientific Marketing, Wuhan, China, ³Siemens Healthcare GmbH, MR Application Development, Erlangen, Germany

Feasibility and accuracy of confounder-corrected 3D multi-echo-Dixon (ME-Dixon) imaging and T2-corrected multi-echo single-voxel (HISTO) spectroscopy for the quantification of liver iron content at 3T MRI were investigated in rabbits with or without fatty liver, compared with conventional 2D multi-gradient-echo (2D GRE) imaging, using histopathology as a reference. The results showed that compared with HISTO (R2_water) method, the multi-echo Dixon (R2*) method was found to be superior for liver iron and fat evaluations. AUC calculations showed that both the ME-Dixon and 2D GRE values had high accuracy for diagnosing liver iron overload in the rabbit model for LICs up to 7mg/g.

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