Abstract #2746

A digital brain perfusion phantom for validation of ASL data post-processing software

Chenyang Zhao¹, Ze Wang², and Danny Wang¹

¹Laboratory of Functional MRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, ²Department of Diagnostic Radiology and Nuclear Medicine, School of Medicine, University of Maryland, Baltimore, MD, United States

A digital brain perfusion phantom was designed using a representative 5-delay 3D pCASL protocol and applied to validate the quantification accuracy of 4 ASL post-processing software packages, including ASLtbx, ASL_MRICloud, BASIL, and Cereflow. The 4 tested software can produce generally correct quantification results under normal SNR conditions, however their accuracy may be affected by the limitation occurred in low perfusion regions and low SNR condition. The digital phantom provides a reliable reference with high flexibility to validate ASL post-processing software.

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