Abstract #2743

Reduced Cerebral Blood Flow in Patients with Pulmonary Arterial Hypertension

Bhaswati Roy¹, Susana Vacas¹, Kathy McCloy², Rajan Saggar², and Rajesh Kumar^1,3,4,5

¹Anesthesiology, University of California Los Angeles, Los Angeles, CA, United States, ²Medicine, University of California Los Angeles, Los Angeles, CA, United States, ³Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, ⁴Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ⁵Brain Research Institute, University of California Los Angeles, Los Angeles, CA, United States

Pulmonary arterial hypertension (PAH) patients show cognitive and mood impairments, and brain tissue injury in those areas. However, the underlying cause of tissue damage in PAH patients remain unclear. Altered cerebral blood flow (CBF) may contribute to develop brain tissue injury and cognitive and mood deficits. We evaluated CBF in PAH patients over controls, and found changes in the prefrontal cortices, insula, cingulate, frontal cortex, corona radiate, temporal, occipital, and parietal gyrus. Significant correlations also emerged between CBF and functional deficits in PAH, including mood and cognition symptoms, implying altered hemodynamic contributing to brain changes and functional deficits.

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