Abstract #2718

Systematic investigation of the sensitivity of optimised pCASL protocols to macrovascular contamination

Logan Xin Zhang¹ and Michael A Chappell^1,2,3

¹Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ²Radiological Sciences, Division of Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ³Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom

Optimised pCASL protocols may still be sensitive to macrovascular contamination (MVC), leading to high CBF estimation error. In this study, we conducted a systematic investigation of CBF sensitivity to MVC from a comprehensive set of optimal pCASL protocols. The general kinetic model was only robust for CBF estimation when tissue ATT was less than 1.5s. An extended kinetic model could reduce CBF sensitivity to up to 2.3s. The results of CBF sensitivity maps could be used for examining a protocol for possible MVC effects before scanning, or data interpretation afterwards.

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