There is emerging evidence that demonstrate spatial and temporal characteristics of the positive BOLD responses, however, the accompanying negative BOLD responses (NBR) are still under investigation. This is surprising since studies investigating NBR started as early as the introduction of the BOLD-fMRI. While there are limited number of studies that have utilized NBR in the normal aging and Alzheimer’s disease, we feel the NBR has not been used to its full capacity in the field. Recently, within the past two years, the number of publications on NBR has increased, making the timing of this research appropriate.
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