Abstract #2575

Inhomogeneous Magnetization Transfer (ihMT) MRI and Coherent Anti-stoke Raman Scattering (CARS) microscopy applied on LPC demyelinating model

Andreea Hertanu^1,2, Cem Karakus^3,4, Lucas Soustelle^1,2, Victor N. D. Carvalho^1,2,5, Gopal Varma⁶, David C. Alsop⁶, Bilal El Waly^3,4, Olivier M. Girard^1,2, Franck Debarbieux^3,4, and Guillaume Duhamel^1,2

¹Aix Marseille Univ, CNRS, CRMBM, Marseille, France, ²APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, ³Aix Marseille Univ, CNRS, INT, Marseille, France, ⁴Aix Marseille Univ, CNRS, CERIMED, Marseille, France, ⁵Aix Marseille Univ, CNRS, ICR, Marseille, France, ⁶Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Intoxication of oligodendrocytes with lysophosphatidylcholine (LPC) is a useful model for the study of focal demyelination and more recently, neuronal damage. We propose an ihMT-CARS analysis on a rodent model of LPC-induced demyelination and a quantitative (T₁, T₂ and T_1D, the dipolar relaxation time) characterization of the demyelinated area.

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