In our study, we used the ultra-high field magnetic imaging to show the brain functional and structure has changed in the rats of chronic pain model. then we also find the expression levels of the protein marker p-Erk has changed in some brain region, including insula, NAc, S1 and so on, and insula has been shown more significant activation. This results are same to the MRI functional data analysis. Finally, we hope to combine MRI and cell imaging technique could to verify the importance of insula in non-human chronic pain.
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