Abstract #2566

High-Resolution, Whole-Brain T1 and T2 Mapping of Monkey Using 3D Magnetic Resonance Fingerprinting at 9.4 T

Yuning Gu¹, Lulu Wang², Hongyi Yang², Yun Wu², Yong Chen³, Kai Zhong², and Xin Yu^1,3,4

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China, ³Radiology, Case Western Reserve University, Cleveland, OH, United States, ⁴Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

A 3D MRF method was developed for T₁ and T₂ mapping of the entire monkey brain with high spatial resolution (0.35x0.35x1 mm³). A conformal head coil was used for improved SNR, which enabled a 24-fold acceleration in data acquisition. B₁ inhomogeneity was corrected in dictionary matching. Comparison of the T₁ and T₂ maps showed a ~20% reduction of T₂ in the globus pallidus of 6-year-old monkeys compared to 4-year-old monkeys.

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