Abstract #2525

Severity of Tubular Atrophy and Fibrosis in Acute Kidney Injury Revealed by Multi-parametric MRI

Feng Wang^1,2, Tadashi Otsuka³, Zhongliang Zu^1,2, Mark P de Caestecker³, Raymond C Harris³, Takamune Takahashi³, and John C Gore^1,2

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ³Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, United States

Acute kidney injury (AKI) is a predictor of mortality, often resulting in incomplete recovery, giving rise to chronic kidney disease (CKD). AKI is defined in clinical practice as a rapid decline in kidney function that occurs over a 7-day period or less, but concerns about the risks of renal biopsies in patients with AKI have limited our ability to identify diagnostic features that are predictive of CKD progression. Multi-parametric MRI, including quantitative spin-lock imaging, relaxometry, and magnetization transfer, can be used to identify features of experimental AKI that are predictive of CKD progression without need for renal biopsy.

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