Single loop coil was optimized in 3D shape to fitting rodent bran geometry and designed in slim and large center opening to meet the requirement of simultaneous fMRI and optical imaging. Relative to conventional 2D flat loop, the proposed 3D design may allow setting a loop coil closer to rat cerebral hemispheres and save more overhead space for optical imaging configuration than a 2D flat coil while keeping B1 perpendicular to B0. Our 3D-shape modification exhibited significant improvement in overall SNR and signal homogeneity especially in cortical areas and center brain in T2-weighted images, EPI and field maps.
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