Abstract #2477

Device and simulation workflow for validating cardiac magneto-stimulation thresholds in porcine models

Valerie Klein^1,2, Mathias Davids^1,2,3, Donald Straney², Livia Vendramini², Lothar R. Schad¹, Maaike van den Boomen^2,3,4, Christopher Nguyen^2,3,4, Lawrence L. Wald^2,3,5, and Bastien Guerin^2,3

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Charlestown, MA, United States, ⁵Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

We developed a magnetic stimulator to measure cardiac stimulation (CS) thresholds of time-varying magnetic fields in pigs. The stimulator consists of a high-power capacitor bank (C=110 µF) discharging into a pancake coil. We will use the measured thresholds to validate a previously developed CS simulation framework that combines electromagnetic field simulations with electrophysiological models of excitable cardiac fibers. We generate whole-body porcine voxel models from multi-bed MRI Dixon and CINE acquisitions to reproduce the anatomy and posture of the animals in our simulations. Carefully validated CS simulations may eventually be useful in setting cardiac safety limits for MRI gradient applications.

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