Abstract #2470

Investigating time dependent diffusion, microscopic anisotropy and T2 effects in the mouse heart

Henrik Lundell¹, Samo Lasič^1,2, Filip Szczepankiewicz^3,4,5, Beata Wereszczyńska⁶, Matthew Budde⁷, Erica Dall'Armellina⁶, Nadira Yuldasheva⁶, Jürgen E. Schneider⁶, and Irvin Teh⁶

¹Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, ²Random Walk Imaging, Lund, Sweden, ³Clinical Sciences, Lund University, Lund, Sweden, ⁴Harvard Medical School, Boston, MA, United States, ⁵Brigham and Women's Hospital, Boston, MA, United States, ⁶Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, ⁷Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States

Non-invasive characterization of cardiac microstructure by diffusion MRI has provided insights into the healthy and diseased heart. Multidimensional diffusion encoding (MDE) aims for measurements with independent contrasts for specific effects. We suggest a battery of MDE measurements that probe diffusivity and microscopic anisotropy at different diffusion and echo times. We show a clear effect of time-dependent diffusion but a smaller effect from transversal relaxation.

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