The mixing time for double diffusion encoding (DDE) should be set low to reduce the relaxation effects but also high enough for estimating microscopic fractional anisotropy. We tested the adequacy of the mixing time of 30 msec by comparing acquisitions with parallel and anti-parallel directions as well as with orthogonal and collinear directions. Relatively short mixing time for our cohort was adequate to evaluate the microscopic fractional anisotropy not only in the normal brain area of the white matter and the central gray matter, but also in pathologically abnormal areas such as brain tumors.
This abstract and the presentation materials are available to members only; a login is required.