Abstract #2391

Decoupling of global brain activity and cerebrospinal fluid (CSF) flow was evident in Parkinson’s cognitive decline

Feng Han¹, Gregory L Brown^2,3, Yalin Zhu¹, Aaron Belkin-Rosen¹, Mechelle M Lewis^3,4, Guangwei Du³, Yameng Gu¹, Paul J Eslinger^3,5, Richard B Mailman^3,4, Xuemei Huang^3,4,5,6,7,8, and Xiao Liu^1,8

¹Department of Biomedical Engineering, The Pennsylvania State University, State College, PA, United States, ²Department of Engineering Science and Mechanics, The Pennsylvania State University, State College, PA, United States, ³Department of Neurology, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA, United States, ⁴Department of Pharmacology, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA, United States, ⁵Department of Radiology, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA, United States, ⁶Department of Neurosurgery, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA, United States, ⁷Department of Kinesiology, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA, United States, ⁸Institute for Computational and Data Sciences, The Pennsylvania State University, State College, PA, United States

Deposition and spreading of misfolded proteins have been linked to cognitive dysfunction in Parkinson’s disease (PD). The glymphatic system responsible for removing brain wastes thus may play a role in cognitive impairment in PD. This hypothesis is however difficult to test in clinical populations due to the lack of non-invasive measurements of glymphatic function. Low-frequency (< 0.1 Hz) resting-state fMRI (rsfMRI) signal was recently linked to glymphatic function primarily based on its sleep-dependent coupling with CSF flows. This study found early evidence that the coupling of global rsfMRI and CSF signals is indeed related to cognitive decline in PD.

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