Abstract #2371

Reduced cerebrovascular reactivity and cerebral blood flow in White Matter Hyperintensities (WMHs)

Chenyang Li^1,2, Marco Muccio¹, Dengrong Jiang³, Peiying Liu³, Jiangyang Zhang¹, Arjun Masurkar⁴, Thomas Wisniewski⁴, Hanzhang Lu³, and Yulin Ge¹

¹Department of Radiology, Center for Biomedical Imaging, NYU Grossman School of Medicine, New York, NY, United States, ²Vilcek Institute of Graduate Biomedical Sciences, NYU Grossman School of Medicine, New York, NY, United States, ³Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ⁴Department of Neurology, NYU Grossman School of Medicine, New York City, NY, United States

Understanding of in vivo vascular pathophysiology in white matter hyperintensities (WMHs) is still incomplete. Compared to grey matter, white matter is considerably less vascularized and tends to have lower blood flow. Therefore, sensitive detection and accurate estimation for white matter hemodynamics is crucial for early prevention and mechanistic understanding of WMHs pathogenesis and progression. In this study, we implemented advanced neurovascular MRI techniques to evaluate the white matter hemodynamics including cerebral blood flow and cerebrovascular reactivity in patients with varying degrees of WMHs.

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