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Abstract #2361

High resolution imaging of choroid plexus blood flow with multi-delay pseudo-continuous arterial spin labeling

Xingfeng Shao1, Chenyang Zhao1, Matthew Borzage2, Catherine Mark3, Elizabeth Joe4, Jonathan Russin3,5, Charles Liu3,4,5, Darrin Lee3,5,6, and Danny JJ Wang1,4
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 3Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 4Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 5USC Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 6Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

In this study we developed an arterial spin labeling (ASL) sequence with high spatial/temporal resolution and utilized a post-processing denoising method to measure dynamic choroid plexus (CP) perfusion signal. Quantified CP blood flow was evaluated in heathy subjects and one normal pressure hydrocephalus (NPH) patient and compared with water exchange rate across the blood-brain barrier (BBB). Our preliminary results show that CP blood flow may be altered in NPH and has a potential relation with water exchange rate across the BBB.

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