Abstract #2342

Intravoxel incoherent motion diffusion-weighted MR imaging for preoperatively identifying CK19-positive hepatocellular carcinoma

Ying Zhao¹, Ailian Liu¹, Wenjing Qi², Xue Ren¹, Tao Lin¹, and Qingwei Song¹

¹The First Affiliated Hospital of Dalian Medical University, Dalian, China, ²Department of Pathology, The First Affiliated Hospital, Dalian Medical University, Dalian, China

Cytokeratin 19 (CK19) is well acknowledged as a biliary/progenitor cell marker and a marker of tumor stem cell. CK19-positive HCCs demonstrate more aggressive behaviors and poorer outcomes. This worked aimed at exploring the value of intravoxel incoherent motion (IVIM) diffusion-weighted (DW) magnetic resonance (MR) imaging in the diagnosis of CK19-positive HCC. The results showed that Slow ADC Mono and Slow ADC Bi were significantly different between the CK19-positive and CK19-negative HCC groups. The area under the curves (AUCs) of Slow ADC Mono, Slow ADC Bi, and combine (Slow ADC Mono & Slow ADC Bi) were 0.817, 0.988, and 0.992, respectively.

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