Clinical diagnosis and real-time evaluation of chemotherapy response for rectal cancer remain challenging due to the lack of effective non-invasive examinational means. The quantitative T2 mapping technique is an effective method for MRI relaxometry in tissues. In this study, we demonstrated that T2 values were significantly higher in rectal cancer than those in the healthy rectal wall, and significantly increased after chemotherapy. Therefore, quantitative T2 mapping might be a promising non-invasive method in the diagnosis and chemotherapy response tracking of rectal cancer.
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