On the repeatability and reproducibility of SPECIAL-based in-vivo spectroscopy with different adiabatic inversion pulses 

This work assesses the test-retest repeatability and reproducibility of spectral shapes and neurochemical profiles of the SPECIAL ¹H MR spectroscopy sequence employing three different adiabatic pulses in-vivo at 7T: the standard hyperbolic secant pulse and two gradient-modulated pulses, namely a GOIA and a WURST pulse. Nine healthy volunteers were scanned four times each, with all three SPECIAL variants to establish three different repeatability or reproducibility measures and to evaluate the limits in the precision of the resulting metabolite quantification.