Abstract #2227

The Correlation of Neurometabolites on Presentation of Post-Concussion Phenotypes

Katherine Breedlove¹, David R Howell², Inga K Koerte^3,4, Eduardo Coello⁴, Molly Charney⁴, Huijin Liao⁴, Corey Lanois⁵, and Alexander Lin⁴

¹Radiology, Brigham and Women's Hospital, Boston, MA, United States, ²Childrens Hospital Colorado, Aurora, CO, United States, ³Ludwig-Maximilians-Universitat, Munich, Germany, ⁴Brigham and Women's Hospital, Boston, MA, United States, ⁵Boston Children's Hospital, Boston, MA, United States

A population of collegiate athletes was evaluated post-concussion for neurometabolic levels in the PCG by magnetic resonance spectroscopy (MRS) and Post-Concussion Symptom Scale (PCSS) following injury. Evaluations were conducted within 72 hours of diagnosed concussion with a follow-up two months after injury. Correlations between neurometabolic concentration and PCSS composite scores were explored. For the purpose of this work, focus was given to the concentrations and concentration ratios of total NAA (NAA+NAAG), total Glutamate (Glu+Gln), and Glutamate (Glu). The change in metabolites between the two time points was also computed.

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