Abstract #2223

1H MRS of the Pediatric Brain Metabolism During Cardiopulmonary Bypass (CPB) Surgery

Daniel Spielman¹, Phil Adamson², Ralph Hurd¹, Meng Gu¹, Kirk Riemer³, Ryan Beckman³, Michael Ma³, Kenichi Okamura³, and Frank Hanley³

¹Radiology, Stanford University, Stanford, CA, United States, ²Electrical Engineering, Stanford University, Stanford, CA, United States, ³Cardiothoracic Surgery, Stanford University, Stanford, CA, United States

We used single-voxel ¹H MRS at 3T to study acute brain metabolic changes during cardiopulmonary bypass (CPB) surgery in a neonatal piglet model, with the overall goal of determining optimal surgical parameters for minimizing brain injury. The recent improvements in proton spectroscopy and MR scanner performance allowed robust measurement of dynamic brain water and metabolic changes during hypothermia and circulatory arrest. Key findings include a linear relationship between unsuppressed water and brain temperature, observation of the theoretically predicted NMR “powder pattern” from intravascular water during hypoxia, and quantitative measurements of glucose, lactate, and phosphocreatine metabolic rates vs temperature.

This abstract and the presentation materials are available to members only; a login is required.

Join Here