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Abstract #2218

1H MR spectroscopic imaging for identifying diffuse abnormalities in mild traumatic brain injury: initial results from a reproducibility study

Anna M Chen1, Teresa Gerhalter1, Seena Dehkharghani1,2, Rosemary Peralta1, Fatemeh Adlparvar1, Martin Gajdošík3, Mickael Tordjman1,4, Julia Zabludovsky1, Sulaiman Sheriff5, James S Babb1, Tamara Bushnik6, Jonathan M Silver7, Brian S Im6, Stephen P Wall8, Guillaume Madelin1, and Ivan I Kirov1,2,9
1Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 2Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States, 3Department of Biomedical Engineering, Columbia University School of Engineering and Applied Science, New York, NY, United States, 4Department of Radiology, Cochin Hospital, Paris, France, 5Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, United States, 6Department of Rehabilitation Medicine, New York University Grossman School of Medicine, New York, NY, United States, 7Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States, 8Ronald O. Perelman Department of Emergency Medicine, New York University Grossman School of Medicine, New York, NY, United States, 9Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States

We present initial results from a reproducibility study of 1H MRSI in mild traumatic brain injury. In line with previous investigations in a separate cohort, linear regression analysis revealed white matter differences between patients and controls, which persisted when comparing only non-recovered patients to controls. In contrast to previous findings, however, the differences were not in N-acetyl aspartate (NAA), but in the glial markers creatine (Cr), choline (Cho), and myo-inositol (mI). Correlations were found between metabolites and neuropsychological testing in grey matter (GM), and between metabolites and symptomatology in white matter (WM).

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Abstract