Abstract #2214

Mapping of differential metabolic regions of RRMS patients in multi-slices dimensional using Spiral-MRSI technique

Oun Al-iedani^1,2, Jeannette Lechner-Scott^2,3,4, Rodney Lea², Ovidiu Andronesi⁵, and Saadallah Ramadan^2,6

¹School of Health Sciences, University of Newcastle, Newcastle, Australia, ²Hunter Medical Research Institute, Newcastle, Australia, ³Department of Neurology, John Hunter Hospital, Newcastle, Australia, ⁴School of Medicine and Public Health, University of Newcastle, Newcastle, Australia, ⁵Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States, ⁶Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia

The study designed a novel multi-dimensional metabolic mapping using multi-slice-spiral-MRSI with multi-voxel segmentation and differential metabolic regions(DMRs) techniques to demonstrate the true nature of NAWM and WM-lesions of RRMS patients,compared to HCs. 3D-spiral-MRSI covering majority of the brain in 16 RRMS and 13 HCs were used. Multi-slice-MRSI was processed using novel pipeline with DMRs classifications. Neurometabolic mapping of multi-DMRs revealed that(NAA/tCr) in WM-lesions was significantly lower than NAWM-MS and HCs,while (m-Ins/tCr) in WM-lesions were significantly higher than NAWM-MS and HCs. Multi-slice-spiral-MRSI coupled with DMRs may enhance a clinical monitoring of RRMS patients, and is sensitive in diagnosing NAWM in RRMS

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