Water suppression is a necessary component to magnetic resonance spectroscopy experiments due to its roughly 5000-fold higher intensity than the metabolites of interest. Here we introduce a novel algorithm for water suppression which operates in a similar manner to that originally proposed by WET and expanded upon by VAPOR, but is flexible in that it can accommodate an arbitrary number of RF pulses, minimum duration between pulses, total module duration and maximum flip angles. This method is referred to as Constrained Optimized Water Suppression. We demonstrated the improvement of COWS over the gold standard VAPOR in simulations and in vivo.
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