Diffusion-weighted NMR spectroscopy allows non-invasive measurement of the diffusion properties of brain metabolites. Lactate is of particular interest but has low concentration thus requiring the development of new sequences to maximize signal-to-noise ratio. In this work, we compare a reference stimulated echo sequence and two spin echo sequences using either a broad pulse, or a selective polychromatic pulse suppressing J-modulation, by measuring the signal attenuation as a function of diffusion-weighting. Suppression of J-modulation with the polychromatic spin echo sequence leads to a significant signal gain and a better precision in lactate signal attenuation.
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