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Abstract #2137

Detection of liver fibrosis in a Rat NASH Model using water specific T1 mapping with Gadoxetic Acid -enhanced MRI

Qian Wan1,2, Hao Peng 1, Jianxun Lyu1,2, Xiaoyi Liu3, Chuanli Cheng1, Feng Liu3, Yangzi Qiao1, Hairong Zheng1, Xin Liu1, Yi Wang3, and Chao Zou1
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Shenzhen College of Advanced Technology,University of Chinese Academy of Sciences, Shenzhen, China, 3Peking University People's Hospital, Beijing, China

The severity of live fibrosis is one of the most important prognostic factors for the long-term outcomes of Nonalcoholic steatohepatitis (NASH). Early and precise diagnosis is of crucial importance for the disease management of NASH patients. In this work, we detected the liver fibrosis using water specific T1 mapping with Gadoxetic Acid -enhanced MRI in a rat NASH model induced by methionine-choline deficient (MCD) diet. The study revealed that the reduction rates of water-T1 relaxation time before and after Gd-EOB-DTPA administration might be a useful tool to stage the mild and moderate live fibrosis in rat NASH model.

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