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Abstract #2130

A New Diffusion-based Elastography for Quantitatively Assessing Liver Fibrosis without External Devices in a Large Set of Patients

Jie Yuan1, Fan Mo2, Yongming Dai2, Yuan Feng3, Suhao Qiu3, Songhua Zhan1, and Zhigang Gong1
1Department of Radiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, China, 2MR Collaboration, United Imaging Healthcare, Shanghai, China, 3Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China

Due to the non-invasive superiority, Magnetic Resonance Elastography (MRE) has emerged as an alternative approach to liver biopsy, the current golden standard for staging liver fibrosis. However, the use of external vibration devices brings costs of scan time and money. Diffusion Weighted Imaging (DWI) has shown the potential to characterize liver fibrosis at a microscopic level recently. The purpose of this study is to evaluate the potential of DWI to provide quantitative estimates of tissue stiffness without external devices among patients with different types of liver fibrosis and compare the inter-method agreement between MRE and the proposed method.

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