Abstract #2120

Influence of portal vein occlusion on portal flow and liver elasticity in an animal model

Simon Chatelin¹, Raoul Pop^2,3, Céline Giraudeau², Khalid Ambarki⁴, Ning Jin⁵, François Séverac^1,6, Elodie Breton¹, and Jonathan Vappou¹

¹ICube, UMR 7357 CNRS, University of Strasbourg, Strasbourg, France, ²IHU-Strasbourg, Institute of image-guided surgery, Strasbourg, France, ³Interventional Neuroradiology Department, University Hospitals of Strasbourg, Strasbourg, France, ⁴Siemens Healthcare SAS, Saint Denis, France, ⁵Siemens Medical Solutions USA, Inc., Chicago, IL, United States, ⁶Public Healthcare Department, University Hospitals Strasbourg, Strasbourg, France

Hepatic fibrosis causes an increase in the liver stiffness, a parameter measured by elastography and widely used as diagnosis method. This study aims at determining the extent to which a portal occlusion due to concomitant portal vein thrombosis can also affect these mechanical properties. Portal vein occlusion was generated by progressive inflations of a balloon catheter in the portal vein of four swines. The portal flow and liver stiffness were investigated using 4D-flow MRI and MR-Elastography. This vascular mechanism is shown to be sufficient to attenuate the increase in stiffness due to moderate fibrosis and may lead to false-negative diagnosis.

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