Abstract #2055

Assessment of Perivascular Glymphatic System Activity in Middle-aged HIV Infected Patients on Combination Antiretroviral Therapies

Benedictor Alexander Nguchu¹, Jing Zhao ^2,3, Yanming Wang¹, Jean de Dieu Uwisengeyimana¹, Xiaoxiao Wang¹, Bensheng Qiu¹, and Hongjun Li^2,3

¹Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, China, ²Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, China, ³School of Biological Science and Medical Engineering, Beihang University, Beijing, China

The brain activity underlying cognitive processing can be affected by HIV. We examine the ALPS index, a measure reflecting glymphatic system activity, along the perivascular space and its relationship with cognitive performance in middle-aged HIV infected patients successfully adhering to antiretroviral therapy. We found that the ALPS index was increased significantly in middle-aged HIV-infected patients receiving cART and was correlated with attention and working memory. The duration on cART was also associated with some cognitive measures. These findings suggest that ALPS index might provide an impetus for understanding cognitively relevant diffusivity changes following HIV or long-term use of cART.

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