Meeting Banner
Abstract #2031

Is calibration necessary to relate NODDI, NODDIDTI, WMTI to axonal volume fraction? - A joint ex vivo MRI and histology study.

Sebastian Papazoglou1, Mohammad Ashtarayeh1, Martina F. Callaghan2, Mark D. Does3,4,5,6, and Siawoosh Mohammadi1,7
1Department of Systems Neurosciences, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 3Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 4Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 5Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 6Department of Electrical Engineering, Vanderbilt University, Nashville, TN, United States, 7Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

It is unknown whether the accuracy of DWI-model based estimates of the axonal water fraction could be enhanced by additional calibrations. In this study we compared three DWI-models (WMTI, NODDI, NODDIDTI) using histology data as gold standard in ex vivo mouse models with a broad dynamic range of axonal metrics. We found that all DWI-models improved with additional calibration. Models with fixed diffusivities benefited efficiently from an additional scaling, while the WMTI model was stronger affected by an additional offset. Furthermore, without any additional calibration, the axonal compartment biomarker from NODDIDTI could explain the data better than WMTI or NODDI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here

Abstract