Spectral registration is a powerful frequency and phase offset correction method. Diffusion-weighted MRS (dMRS) provides a particularly stern challenge for drift correction due to the lower SNR, varying lineshape, and increased gradient-induced frequency drift. Here, simulated data are used to examine spectral registration and its new robust iteration in the context of dMRS. The accuracy of these methods is examined across a broad range of SNR, and the effect they have on ADC estimates, investigated.
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