Abstract #1993

Detection and quantification of NAD+ in the human brain at 3 T: Comparison of three different localization techniques

Martyna Dziadosz¹, Maike Hoefemann¹, André Döring², Malgorzata Marjanska³, Edward Auerbach³, and Roland Kreis¹

¹Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, ²Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, ³Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minnesota, MN, United States

The detection and quantification of Nicotinamide adenine dinucleotide (NAD⁺) was demonstrated to be challenging in ¹H Magnetic Resonance Spectroscopy, due to its low concentration and reported polarization exchange with water. Frequency-selective excitation with slice-selective refocusing was proposed to prevent saturation-transfer from water. In this study we compare three techniques to access NAD⁺ quantification – standard WS semiLASER and two nWS (MC semiLASER and 2D I-CSE). NAD⁺ was detected with all techniques with a limited visibility for the WS semiLASER. While utilizing nWS concept allows to detect NAD⁺ at the visibility of 66%.

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