Abstract #1988

GOIA-WURST optimisation for ultra-high field single-voxel MRS at short-TE

Adam Berrington¹, Joseph S Gillen^2,3, and Vincent Boer⁴

¹Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ²Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United Kingdom, ³F.M. Kirby Research Centre, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Danish Research Centre for Magnetic Resonance,Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark

Gradient modulated pulses allow for accurate slice localisation in single-voxel MRS. However, they suffer from ‘smearing’ artifacts at off-resonance leading to poor performance across the inversion band, particularly when B₁ field strength is low. An optimized GOIA-WURST pulse shape was found by simulating changes in the modulation parameters to improve the off-resonance profile at 7T for B₁ of 15 μT. When used in a semi-LASER localisation, the optimised GOIA(50,10) pulses resulted in a minimum TE of 23 ms which led to upright peak shapes for J-coupled multiplets in phantom.

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