Morphologic alterations of AD have been conventionally associated with the cerebral cortex; however, it is clear that other areas of the brain, especially the hippocampus are also involved. These structures, together with white matter structures including fornix constitute the limbic system, which is anatomic substrate of the memory system. Neurodegeneration in these areas lead to clinical manifestation of AD. In this study, we evaluated integrity of the limbic-associated areas in three groups using DTI. Findings yielded that the DTI-derived indices of the limbic-associated areas offer potential biomarkers for early and differential diagnosis of AD.
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