Abstract #1939

1-Norm for quantifying the degree of brain tissue mechanical inhomogeneity due to neurodegenerative disease

Harish Palnitkar¹, Shreyan Majumdar², Rolf Reiter³, Shujun Lin², Joseph Crutison², Thomas Royston², and Dieter Klatt²

¹Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL, United States, ²Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ³Charite Universitatsmedizin, Berlin, Germany

In prior investigations, we have established 1-Norm as a quantitative measure of degree of inhomogeneity of excised biological tissues. Here, we apply 1-Norm to study effect of Alzheimer’s disease on mechanical inhomogeneity of brain. MRE was performed on excised brains of 3 control mice & 3 mice with AD(5xFAD). 1-Norm revealed increase in mechanical inhomogeneity of brain tissue due to AD. We speculate this increase in mechanical inhomogeneity of brains with AD may be due to amyloid plaque deposition, synaptic degeneration, neuronal loss & loss of white matter tracts. We aim to establish 1-Norm as a biomarker to detect AD in humans.

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