Synthetic MRI is a novel method that simultaneously provides quantitative relaxation mapping and synthetic contrast-weighted images. In this study, we adopted this technique to investigate the age-related relaxation characteristics alterations in healthy subjects by brain region-based regression analysis. Specifically, we found significant differences of relaxation characteristics between left and right hemispheres in the frontal and occipital white matter, and the genu and splenium of corpus callosum. T1, T2 and PD showed a quadratic trend with age. Overall, our findings suggested that the relaxation characteristics provided by the synthetic MRI can be considered an effective tool for detecting brain aging.
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