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Abstract #1930

Application of SVS-PRESS, MEGA-PRESS, and pCASL to Evaluate Treatment Effect of Kami Guibi-tang in Patients with Mild Cognitive Impairment

Geon-Ho Jahng1, Seung-Yeon Cho2, Jung-Mi Park2, Soonchan Park1, Chang-Woo Ryu1, and Richard Edden3
1Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, 2Stroke and Neurological Disorders Center, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, 3Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

This study aims to evaluate the effectiveness of herb medicine in the treatment of mild cognitive impairment (MCI) using SVS PRESS MRS, MEGA-PRESS, and pCASL MRI. We randomly allocated a total of 30 MCI patients to an herb medicine or a placebo group and performed MRI scans before and after 24 weeks of treatment. We analyzed NAA/Cr, GABA/Cr, and cerebral blood flow (CBF) using repeated-measure analysis of variance (ANOVA). We found that the CBF measures were the most sensitive markers to evaluate the effect of the herb medicine on MCI.

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