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Abstract #1924

Multimodal MR imaging reveals distinct sensitivity of hippocampal subfields to normal aging and asymptomatic Alzheimer's disease pathology

Junjie Wu1, Syed S. Shahid2,3, Qixiang Lin2, Antoine Hone-Blanchet2, Jeremy L. Smith1, Benjamin B. Risk4, Aditya S. Bisht2, David W. Loring2, Felicia C. Goldstein2, Allan I. Levey2, Bruce A. Crosson2,5, James J. Lah2, and Deqiang Qiu1,6
1Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 2Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States, 3Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 4Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA, United States, 5Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, GA, United States, 6Joint Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States

Using structural, resting-state functional and diffusion MRI, we report that normal aging affects functional connectivity and tissue microstructure in all hippocampal subfields, while the subiculum and CA1-3 exhibit the greatest sensitivity to asymptomatic Alzheimer’s disease pathology with CA1-3 hyperconnectivity. The imaging measures correlate with neuropsychological performance and CSF tau.

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