Type 2 diabetes mellitus (T2DM) is associated with olfactory dysfunction and cognitive decline. We proposed one functional connectivity (FC) model that links the primary olfactory cortex (POC) to advanced cognition related cognitive brain area. The whole olfactory network was divided into three sub-networks: POC consists of the bilateral anterior olfactory nucleus, piriform cortex, entorhinal cortex, and amygdala; secondary olfactory cortex (SOC) include the bilateral hippocampus, parahippocampus, thalamus, and hypothalamus; advanced olfactory cortex (AOC) consists of bilateral orbitofrontal cortex, insula and dorsolateral prefrontal cortex(DLPFC). Our results suggested that FC was heterogeneously disrupted in the POC-SOC-AOC olfactory pathway in T2DM.
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