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Abstract #1880

Longitudinal MRI and MR Elastography (MRE) Assessment in Patients with Diagnosed Nonalcoholic Fatty Liver Disease (NAFLD)

Zheng Zhu1, Alina M. Allen2, Terry Therneau3, Xin Lu1, Kevin J. Glaser1, Jiahui Li1, Jingbiao Chen1,4, Jie Chen1,5, Safa Hoodeshenas1, Sudhakar K. Venkatesh1, Armando Manduca1,6, Richard L. Ehman1, and Meng Yin1
1Department of Radiology, Mayo Clinic, Rochester, MN, United States, 2Devision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States, 3Devision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States, 4Department of Radiology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangdong, China, 5Department of Radiology, West China Hospital, Chengdu, Sichuan, China, 6Devision of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States

To identify individuals at high risk for rapid fibrosis progression, we retrospectively investigated longitudinal changes in liver stiffness measurements (LSM) and proton density fat fraction (PDFF) in 36 NAFLD patients. At the early fibrosis stages, the rate of change of LSM is slow and positively correlated with the rate of change in PDFF. At later fibrosis stages, the rate of change in LSM is higher and is negatively correlated with ΔPDFF. Compared with other risk factors, the baseline value of LSM and the rate of change in PDFF was most strongly correlated with subsequent change in LSM.

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Abstract