Abstract #1733

Comparing Methods for Ultra-High Resolution Structural Imaging of Human Olfactory Bulb and Tract at 3T

Sichen Ludwig Zhao^1,2, Jay A Gottfried², John A Detre², and M Dylan Tisdall³

¹Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States, ²Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

The olfactory bulbs (OBs) and tracts transmit odor information from the nose to the brain and plays a key role in learning, memory, and emotion. In vivo imaging of the human olfactory bulbs (OBs) is inherently challenging due to their limited size and high susceptibility gradients at the basal frontal lobes. We compare three sequences (T2 SPACE, CISS, and T1-weighted PETRA) to produce the highest-resolution (440um) structural images of the human olfactory bulb at 3 T. We demonstrate that these images offer robust visualization of the olfactory bulbs and tracts that projects to the medial temporal lobes.

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