Abstract #1718

In Vivo Diffusion Tensor Distribution MRI of the Human Brain Using 300 mT/m Gradients

Kulam Najmudeen Magdoom¹, Alexandru V. Avram¹, Dario Gasbarra², Qiuyun Fan³, Thomas Witzel³, Susie Y Huang³, and Peter J Basser¹

¹National Institute of Health, Bethesda, MD, United States, ²University of Helsinki, Helsinki, Finland, ³Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

Measuring and mapping the diffusion tensor distribution (DTD) via MRI holds the promise of revealing the tissue microstructure at sub-voxel resolution. In this study, we show the DTD results obtained on a human brain in-vivo using the new framework at MGH Connectome scanner with 300 mT/m gradients. The DTD within a voxel is assumed to be a normal tensor variate distribution constrained (CNTVD) within the manifold of 3 x 3 symmetric positive definite matrices. The estimated DTD is used to obtain a family of metrics which aim to disentangle size, shape and orientation heterogeneities present within a voxel.

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