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Abstract #1714

Technical performance of ADC and IVIM measurements in glioma and normal brain on a 1.5T MR-Linac

Liam S. P. Lawrence1, Rachel W. Chan2, Hanbo Chen3, Brian Keller3, James Stewart3, Mark Ruschin3, Brige Chugh3,4, Mikki Campbell3, Aimee Theriault3, Greg J. Stanisz1,2,5, Scott MacKenzie3, Sten Myrehaug3, Jay Detsky3, Pejman J. Maralani6, Chia-Lin Tseng3, Greg J. Czarnota1,2,3, Arjun Sahgal3, and Angus Z. Lau1,2
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4Department of Physics, Ryerson University, Toronto, ON, Canada, 5Department of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland, 6Department of Medical Imaging, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Technical performance evaluation of diffusion parameters on MR-Linacs (MRLs) is important for cancer applications. We evaluated the accuracy and repeatability of 1.5T MRL measurements of apparent diffusion coefficient (ADC) and intravoxel incoherent motion blood volume fraction (IVIM-f) in the brain via comparison with a diagnostic-quality scanner, in patients undergoing treatment. ADC measurements agree in normal and tumour tissue, but are biased in cerebrospinal fluid. IVIM-f measurements are likely negatively biased. Repeatability is comparable between scanners. The majority of high-grade glioma patients demonstrated significant ADC changes, but not IVIM-f changes.

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