Diffusion tensor imaging (DTI) consistently detects increased mean diffusivity (MD) and decreased fractional anisotropy (FA) with age in single white matter (WM) bundles, but findings have been inconsistent in more complex fibre architecture. In this study, an orthogonal moment tensor decomposition yields clear degeneration patterns across complex fibre architecture, indicating that apparent challenges of DTI in these regions were due to the choice of tensor decomposition rather than the DTI model itself. This study therefore presents a revised view of DTI of aging WM and indicates how degeneration in complex fibre architecture can manifest in forms other than decreased FA.
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